The mechanical behavior of 3D architectured knitted textiles is investigated experimentally and computationally. In this aspect, different imaging methods including microscopy and digital image correlation (DIC) are used to investigate the multiscale behavior of such structures. Local and global kinematics are observed in situ as displacement is applied providing a link between behavior at the two scales by defining the built architecture morphologically, topologically and geometrically. Additionally, Finite Element Analysis (FEA) is used to simulate the geometrical details of the entangled yarns included in the 3D models developed. Parallelized Direct Numerical Simulations (DNS) were run in a high performance computing environment using several numerical methods and are shown to be capable of investigating the influence of local architecture at the yarn level including both loop geometry, yarn to yarn interactions, and global anisotropic response as a result of the geometry. The type and role of contact points as well as the influence of 3D kinematics on the computed mechanical properties are investigated. The results obtained both computationally and experimentally were found to be in good agreement.